A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing

TDP-43 is an RNA-binding protein active in splicing that concentrates into membraneless ribonucleoprotein granules and forms aggregates in amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Although best known for its predominantly disordered C-terminal domain which mediates ALS inclusions, TDP-43 has a globular N-terminal domain (NTD). Here, we show that TDP-43 NTD assembles into hea...

Polymerization-induced phase separation in a liquid-crystal-polymer mixture.

A Novel Stand-Alone Single-Phase Induction Generator Using a Three-Phase Machine and a Single-Phase PWM Inverter

A new type of single-phase stand-alone induction generator using a three-phase induction machine and a single-phase voltage-source PWM inverter is introduced. The generator scheme is capable of producing constant load frequency with a very well regulated output voltage. A small lead acid battery and a single-phase full diode-bridge rectifier are used to feed the inverter. The inverter feeds one...

Phase Separation through Simultaneous Polymerization and Crystallization for Composite Materials

Phase separation of composite materials through simultaneous polymerization and crystallization

Composite materials have attracted much interest because of the emergent properties originating from the components. A variety of methods have been studied to control the morphology of composites based on noncrystalline polymers and crystalline materials. However, it is not easy to control complex morphologies, such as segregated sea-island structures, on the submicrometer scale. Polymerization...